Notizie da LEI

PUBBLICAZIONE PUB MED :Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial – Giugno 2019

Support Care Cancer. 2019 Jun 17. doi: 10.1007/s00520-019-04881-3. [Epub ahead of print]

Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial.

Author information

1Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.
2Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.



Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent clinical problem, with limited effective therapies. Preliminary non-randomized clinical trial data support that Scrambler Therapy is helpful in this situation.


Patients were eligible if they had CIPN symptoms for at least 3 months and CIPN-related tingling or pain at least 4/10 in severity during the week prior to registration. They were randomized to receive Scrambler Therapy versus transcutaneous electrical nerve stimulation (TENS) for 2 weeks. Patient-reported outcomes (PROs) were utilized to measure efficacy and toxicity daily for 2 weeks during therapy and then weekly for 8 additional weeks.


This study accrued 50 patients, 25 to each of the 2 study arms; 46 patients were evaluable. There were twice as many Scrambler-treated patients who had at least a 50% documented improvement during the 2 treatment weeks, from their baseline pain, tingling, and numbness scores, when compared with the TENS-treated patients (from 36 to 56% compared with 16-28% for each symptom). Global Impression of Change scores for “neuropathy symptoms,” pain, and quality of life were similarly improved during the treatment weeks. Patients in the Scrambler group were more likely than those in the TENS group to recommend their treatment to other patients, during both the 2-week treatment period and the 8-week follow-up period (p < 0.0001). Minimal toxicity was observed.


The results from this pilot trial were positive, supporting the conduct of further investigations regarding the use of Scrambler Therapy for treating CIPN.


Chemotherapy-induced peripheral neuropathy; Scrambler; TENS


PUBBLICAZIONE PUB MED -Scrambler therapy for the treatment of diabetic peripheral neuropathy pain: A case report. Maggio 2019

Medicine (Baltimore). 2019 May;98(20):e15695. doi: 10.1097/MD.0000000000015695.

Scrambler therapy for the treatment of diabetic peripheral neuropathy pain: A case report.

Author information

Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Ewha Womans University Mokdong Hospital, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul, Republic of Korea.



Neuropathy secondary to diabetes mellitus often does not respond well to conventional therapy. Scrambler therapy may be an alternative treatment for otherwise intractable neuropathy.


A 45-year-old female complained of bilateral plantar foot pain. She had been treated for diabetes mellitus for 5 years. Oral analgesics did not resolve her pain. Even nerve block therapy did not adequately relieve her pain.


Diabetic peripheral neuropathy.


Scrambler therapy.


Pain reduction; the treatment effect was based around the location of the scrambler patch.


Scrambler therapy is effective for the treatment of diabetic peripheral neuropathy. Moreover, effective pain management can be achieved for patients who complain of general pain of the sole, including the toe, by attaching scrambler patches around the ankle.

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6 – 8 giugno 19 AISD 42°Congresso Nazionale – Roma

6 – 8 giugno 2019

42° Congresso Nazionale AISD
Roma  Hotel Roma Aurelia Antica

Si parlerà di Scrambler Therapy  con l’intervento anche dell’inventore Giuseppe Marineo

Venerdì 7 giugno – Sala Velasquez

15,15-16,15 Dolore cronico un nuovo paradigma nella gestione dei non rispondere
moderatori dott.Riccardo Rinaldi e dott.ssa Filomena Puntillo

15,15 Dentro la Scrambler Therapy dalla teoria del Gate Control al principio attivo dell’informazione
prof. Giuseppe Marineo

15,35 Rilevanza clinica della Scrambler Therapy con pazienti non responder
dott.ssa Maria Rosciano

15,55 Discussione

Scarica il programma completo  dell’evento al link:


PUBBLICAZIONE PUB MED: Inside the Scrambler Therapy, a Noninvasive Treatment of Chronic Neuropathic and Cancer Pain: From the Gate Control Theory to the Active Principle of Information – Aprile 2019

Integr Cancer Ther. 2019 Jan-Dec;18:1534735419845143. doi: 10.1177/1534735419845143.

Inside the Scrambler Therapy, a Noninvasive Treatment of Chronic Neuropathic and Cancer Pain: From the Gate Control Theory to the Active Principle of Information.

1 University of Rome Tor Vergata, Rome, Italy.


Scrambler therapy (ST) is an electro-analgesia therapy for the noninvasive treatment of chronic neuropathic and cancer pain based on a new generation of medical device that uses 5 artificial neurons and is based on a novel theoretical model the differs from gate control theory. The active principle with Scrambler Therapy is such that synthetic “non-pain” information is transmitted by C fiber surface receptors. This is a different theoretical mechanism than the traditional electric stimulation of A-Beta fibers to produce paresthesia and/or block the conduction of nerve fibers to produce an analgesic effect, that is, via TENS (transcutaneous electrical nerve stimulation) machines. Scrambler therapy was developed to treat chronic neuropathic pain and cancer pain resistant to opioids and other types of treatments. The goal of Scrambler Therapy is to eliminate pain during treatment and allow for long-lasting analgesia after a series of 10 to 12 consecutive treatments performed over a 2-week period. The aim of this review is to clarify the underlying theory of Scrambler Therapy and describe the appropriate usage method that maximizes its effectiveness while reducing bias and deepen the explanation of the artificial neuron technology associated with Scrambler Therapy.


Scrambler Therapy; artificial neurons; cancer pain; chronic pain; drug resistance; electro analgesia; gate control theory; neuropathic pain; opioids



Dentro la Scrambler Therapy, un trattamento non invasivo del dolore cronico neuropatico e da cancro. Dalla teoria del gate control al principio attivo dell’informazione.
Titolo originale: Inside the Scrambler Therapy, a non-invasive treatment of chronic neuropathic and cancer pain. From the Gate Control Theory to the active principle of information.

Giuseppe Marineo
Delta Research & Development – University of Rome Tor Vergata, Via di Mezzocammino 85, Rome, Italy, 00127.


La Scrambler Therapy (ST) è una terapia di elettro-analgesia utilizzata per il trattamento non invasivo del dolore cronico neuropatico e oncologico. E’ basata su una nuova generazione di dispositivi medici che utilizza 5 neuroni artificiali, ed un nuovo modello teorico che differisce dalla teoria del Gate Control. Il principio attivo della Scrambler Therapy è un’informazione sintetica di “non-dolore” che viene trasmessa nelle vie del dolore attraverso i recettori di superficie delle fibre C. Questo meccanismo teorico è diverso dalla tradizionale stimolazione elettrica delle fibre A-Beta utilizzato per produrre parestesia e / o bloccare la conduzione delle fibre nervose per produrre un effetto analgesico, cioè quello utilizzato nei dispositivi TENS e negli SCS (stimolatori impiantati).

La Scrambler Therapy è stata sviluppata specificatamente per trattare il dolore cronico neuropatico ed il dolore da cancro resistenti agli oppioidi e ad altri tipi di trattamenti. L’obiettivo della Scrambler Therapy è quello di eliminare completamente il dolore durante il trattamento, e consentire un’analgesia duratura dopo una serie di 10 o 12 trattamenti consecutivi eseguiti in un periodo di due settimane. Lo scopo di questa revisione è quello di chiarire la teoria alla base della Scrambler Therapy, descrivere il metodo di utilizzo appropriato che ne massimizza l’efficacia riducendo le fonti di bias, ed approfondire la spiegazione della tecnologia dei neuroni artificiali associata alla Scrambler Therapy.

Key Words: Artificial Neurons, Cancer Pain, Chronic Pain, Drug Resistance, Electro analgesia, Gate Control Theory, Neuropathic Pain, opioids, Scrambler Therapy.


15 -17 novembre 18 XXV Congresso Nazionale SICP – Riccione

15-17 novembre 2018

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